Entwicklung und klinische Anwendung fortgeschrittener OCT-Technologien
Zu den bahnbrechenden Forschungsergebnissen der Gruppe gehörten die erste Demonstration eines optischen A-Scans (Grundelement eines OCT-Bildes, 1990) und die erste Demonstration von Fourier-Domain OCT-Methoden (Basistechnologie aller modernen OCT-Systeme, 1995). Diese Ergebnisse wurden mit dem Russ-Preis der US National Academy of Engineering ausgezeichnet (2017).
Die gegenwärtige Forschung konzentriert sich auf funktionelle Erweiterungen der OCT wie polarisationsempfindliche OCT, Doppler-OCT, Mehrstrahl-OCT sowie auf hochauflösende Abbildungsmethoden unter Verwendung adaptiver Optik. Unsere Arbeiten zur translationalen OCT umfassen Pilotstudien und größere klinische Studien im Bereich der okulären Bildgebung, die Krankheiten wie altersbedingte Makuladegeneration, Glaukom, diabetische Retinopathie und andere umfassen. Die Arbeiten unserer Forschungsgruppe wurden in ca. 200 Peer-reviewten Artikeln publiziert.
Forschungsbereich
Gruppenmitglieder
Gruppenleiter
Mitglieder
- Gerold Aschinger
- Bernhard Baumann
- Angela Baumgartner
- Florian Beer
- Marco Bonesi
- Charlotte Brouwer
- Ana Rita Carvalho
- Sylvia Desissaire
- Sabine Dichtl
- Wolfgang Drexler
- Félix Fanjul-Velez
- Franz Felberer
- Paul Fuchs
- Martin Fürst
- Erich Götzinger
- Richard Haindl
- Catharina Hauer
- Christoph Hitzenberger (ehemaliger Gruppenleiter)
- Christoph Hofer
- Johannes Jungwirth
- Jana Kainerstorfer
- Julian Kiefer
- Julia-Sophie Kroisamer
- Manfred Kulhavy
- Marie Laslandes
- Alice Motschi
- Rahul Patil
- Hannah Prokesch
- Matthias Rechenmacher
- Matthias Salas
- Muhammad Faizan Shirazi
- Markus Sticker
- Mitsuro Sugita
- Wolfgang Trasischker
- Teresa Torzicky
- Paul Vetschera
- Andreas Wartak
- Stefan Zotter
- The angiofibrotic switch in neovascular age-related macular degeneration (2019)
FWF (Austrian Science Fund), together with Department of Ophthalmology and Optometry (PI) - MERLIN (2017)
EC Horizon 2020 - Individual structure function map using nerve fiber tracing (2017)
FWF (Austrian Science Fund), together with Department of Ophthalmology and Optometry (PI) and CeMSIIS - Polarization sensitive OCT for ocular imaging (2017)
Narayana Nethralaya Foundation - Phase-sensitive multibeam OCT systems (2014)
FWF (Austrian Science Fund)
Ausgewählte Publikationen
Komplette Liste der Publikationen Pircher
- C.K. Hitzenberger: "Optical Measurement of the Axial Eye Length by Laser Doppler Interferometry." Invest. Ophthalmol. Vis. Sci. 32, 616, 1991.
(This paper introduces the optical A-scan, the basis of modern ocular biometry and the basic element of an optical coherence tomography (OCT) scan). - A.F. Fercher, C.K. Hitzenberger, G. Kamp, S.Y. El-Zaiat: "Measurement of Intraocular Distances by Backscattering Spectral Interferometry." Opt. Commun. 117, 43, 1995.
(This paper introduces the Fourier domain optical A-scan and forms the basis of Fourier domain OCT, the industry standard of modern OCT). - E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, C.K. Hitzenberger: "Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography". Opt. Express 16, 16410-16422, 2008.
(This paper is the first to demonstrate automated segmentation of a retinal layer by intrinsic, tissue specific polarization contrast). - M. Pircher, C.K. Hitzenberger, U. Schmidt-Erfurth: "Polarization Sensitive Optical Coherence Tomography in the Human Eye". Prog. Ret. Eye Res. 30, 431-451, 2011.
(This is a comprehensive review paper on polarization sensitive OCT methods used for ophthalmic applications). - F. Felberer, J.S. Kroisamer, B. Baumann, S. Zotter, U. Schmidt-Erfurth, C.K. Hitzenberger, M. Pircher: “Adaptive optics SLO/OCT for 3D imaging of human photoreceptors in vivo”, Biomed. Opt. Express 5, 439-456, 2014.
(This paper is the first to demonstrate OCT imaging of cone photoreceptors in the human fovea centralis and of rod photoreceptors in the human retina).
- Desissaire, Sylvia, Advanced OCT methods for quantification of retinal vascular and tissue properties, PhD thesis, Medical University of Vienna, 2022.
- Wartak, Andreas, Multi-channel optical coherence tomography for retinal imaging, PhD thesis, Medical University of Vienna, 2018.
- Salas, Matthias, Cellular resolution retinal imaging with adaptive optics OCT, PhD thesis, Medical University of Vienna, 2018.
- Haindl, Richard, Multibeam Doppler Optical Coherence Tomography, PhD thesis, Medical University of Vienna, 2017.
- Fürst, Martin, Optical coherence tomography for vascular skin imaging, MSc thesis, Vienna University of Technology, 2017.
- Trasischker, Wolfgang, Phase Sensitive Multichannel OCT, PhD thesis, Medical University of Vienna, 2015.
- Sugita, Mitsuro, Polarization Sensitive Optical Coherence Tomography with Retinal Tracking and Multiple Frame Processing, PhD thesis, Medical University of Vienna, 2015.
- Felberer, Franz, Adaptive Optics Scanning Laser Ophthalmoscopy in Combination with En-face Optical Coherence Tomography, PhD thesis, Medical University of Vienna, 2014.
- Torzicky, Teresa, Polarization Sensitive Optical Coherence Tomography at 1060 nm for retinal imaging, PhD thesis, Medical University of Vienna, 2014.
- De Carvalho, Ana Rita, Evaluation and improvement of the performance of an adaptive opticsscanning laser ophthalmoscope, MSc thesis, Vienna University of Technology, 2014.
- Vetschera, Paul, Implementation of a line-scanning laser ophthalmoscope into an adaptive optics system, MSc thesis, Vienna University of Technology, 2014.
- Rechenmacher, Matthias, Polarization-sensitive adaptive optics enhanced optical coherence tomography with dynamic focus, MSc thesis, Vienna University of Technology, 2014.
- Zotter, Stefan, Functional Extensions of Optical Coherence Tomography, PhD thesis, Medical University of Vienna, 2012.
- Aschinger, Gerold, Adaptive Optics Scanning Laser Ophthalmoscope, MSc thesis, Vienna University of Technology, 2012.
- Kainerstorfer, Jana, Quantitative functional optical imaging of the human skin using multi-spectral imaging, PhD thesis, University of Vienna, 2010.
- Baumann, Bernhard, Polarization sensitive optical coherence tomography in the human eye, PhD thesis, Medical University of Vienna, 2009.
- Erich, Götzinger, Advanced optical coherence tomography techniques in time domain and spectral domain, PhD thesis, University of Vienna, 2007.
- Baumann, Bernhard, Spektrale Optische Kohärenztomographie bei 1310 nm, MSc thesis, University of Vienna, 2009.
- Jungwirth, Johannes, Der Vorderabschnitt des Auges in spektraler optischer Kohärenztomographie, MSc thesis, University of Vienna, 2009.
- Prokesch, Hannah, Integration eines Hartmann-Shack-Wellenfrontsensors in ein Scanning Laser Ophthalmoskop für hochauflösende retinale Diagnostik, MSc thesis, University of Vienna, 2009.
- Kainerstorfer, Jana, Probing the “fast signal” in near infrared spectroscopy, MSc thesis, University of Vienna, 2007.
- Pircher, Michael, Contrasting techniques in optical coherence tomography, PhD thesis, Vienna University of Technology, 2003.
- Götzinger, Erich, Messung und Abbildung doppelbrechender Strukturen mittels phasenempfindlicher Polarisations-Teilkohärenztomographie, MSc thesis, University of Vienna, 2001.
- Markus, Sticker, Phase contrast methods in optical coherence tomography, PhD thesis, Vienna University of Technology, 2001.
- Dichtl, Sabine, Polarisationssensitive Optische Kohärenztomographie in der Zahnheilkunde, MD thesis, University of Vienna, 1998.
- Hofer, Christoph, Messung doppelbrechender Eigenschaften transparenter Medien mittels polarisationsabhängiger Teilkohärenzinterferometrie, MSc thesis, Vienna University of Technology, 1998.
- Kulhavy, Manfred, Messung intraokularer Distanzen mittels durchstimmbarer Single-Mode-Laser, MSc thesis, Vienna University of Technology, 1998.
- Baumgartner, Angela, Signal and resolution enhancements in partial coherence interferometry and optical coherence tomography, PhD thesis, Vienna University of Technology, 1997.
- Drexler, Wolfgang, In vivo optical coherence tomography and topography of the fundus of the human eye, PhD thesis, Vienna University of Technology, 1995.
- Baumgartner, Angela, Messung intraokularer Distanzen am menschlichen Auge mittels Teilkohärenz-Interferometrie, MSc thesis, Vienna University of Technology, 1994.
- Drexler, Wolfgang, Optische Messung des Fundusprofils und der Achsenlänge des Auges mittels Laser-Doppler-Interferometrie, MSc thesis, Vienna University of Technology, 1991.