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Tik Group

  1. Center for Medical Physics and Biomedical Engineering
  2. About Us
  3. Research Groups
  4. Tik Group

Neuroimaging-informed Brain Stimulation

Our mission is to develop and translate technical innovations in Transcranial Magnetic Stimulation and functional Magnetic Resonance Imaging (TMS-fMRI) to inform brain stimulation therapy. Using interleaved TMS-fMRI we developed procedures to measure direct target engagement in stimulated brain regions and networks.

Our approach focuses on personalisation, by adjusting stimulation to the participant’s individualized target, intensity, dosage and timing relative to brain state. We significantly contributed to the advancement of brain stimulation therapy as a precision medicine approach.

For example, we measured differences in individual brain excitability and found that participants engaged in a specific cognitive task showed a stronger response in the DLPFC-ACC axis - the current gold-standard target in depression treatment.

Our group specializes in optimizing hardware and software for interleaved TMS-fMRI. We pioneered the chronometric interleaved TMS-fMRI approach, allowing us to investigate the temporal dynamics of language and cognitive working memory processing.

 

Research Area

Magnetic Resonance

Team members

Principal Investigator

Martin Tik

P +43 (0)1 40400-17950

martin.tik@meduniwien.ac.at

Members

Sarah Grosshagauer
Luna Müller-Hartburg
Rostyslav Samonov
Onisim Soanca
Ella Teuscher
Maria Vasileiadi

  • Intra- and inter-individual moderators of prefrontal excitability investigated using simultaneous TMS with neuroimaging
    Mental Health Research Center, Hong Kong Polytechnic University, Co-I

  • Zielregionen für Transkranielle Magnetstimulation
    FFG (Austrian Research Promotion Agency), Principal Investigator

  • Research Innovation and Sustainable Pan-European Network in Peripartum Depression Disorder
    EU, COST Action 18138, Project Management

  • Calibrated Brain Stimulation by Concurrent TMS/fMRI Stimulation
    Austrian Science Fund (FWF), Co-I

  • ML based optimization for personalized brain stimulation
    Bavaria California Technology Center, PI

Selected peer-reviewed publications

Complete List of Publications Tik

  • Grosshagauer S, Woletz M, Vasileiadi M, Linhardt D., Nohava L., Schuler A, Windischberger C., Williams N., Tik M. “Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects”. Molecular Psychiatry, 2024

  • Vasileiadi M, Schuler AL, Woletz M, Linhardt D, Windischberger C, Tik M. "Functional connectivity explains how neuronavigated TMS of posterior temporal subregions differentially affect language processing”. Brain Stimulation, 2023.

  • Chang K & Tik M, Mizutani-Tiebel Y, Schuler AL, Taylor P, Campana M, Vogelmann U, Huber B, Dechantsreiter E, Thielscher A, Bulubas L, Padberg F, Keeser D. “Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols”. Neuroimage, 2024.

  • Tik M, Woletz M, Vasileiadi M, Linhardt D, Schuler A, Windischberger C. “Concurrent TMS/fMRI reveals individual DLPFC dose-response pattern”. Neuroimage, 2023 Oct 5.

  • Tik M, Woletz M, Schuler A, Vasileiadi M, Cash RFH, Zalesky A, Lamm C, Windischberger C. “Acute TMS/fMRI response explains specific depression network target engagement“. Neuroimage, 2023.

  • Paul K & Tik M, Hahn A, Sladky R, Geissberger N, Seidel E, Kranz GS, Pfabigan DM, Kraus C, Lanzenberger R, Lamm C, Windischberger C. “Give Me a Pain that I am used to: Distinct Habituation Patterns to Painful & Non-painful Stimulation“. Scientific Reports, 2021.

  • Geissberger N & Tik M, Sladky R, Woletz M, Schuler AL, Willinger D, Windischberger C. “Reproducibility of amygdala activation in facial emotion processing at 7T”. Neuroimage,. 2020 May 1.

  • Tik M & Sladky R, Luft CDB, Willinger D, Hoffmann A, Banissy MJ, Bhattacharya J, Windischberger C. “Ultra-high-field fMRI insights on insight: Neural correlates of the Aha!- moment”. Human Brain Mapping, 2018 Apr 17.

  • Tik M, Hoffmann A, Sladky R, Tomova L, Hummer A, Navarro de Lara L, Bukowski H, Pripfl J, Biswal B, Lamm C, Windischberger C. “Towards understanding rTMS mechanism of action: Stimulation of the DLPFC Causes Network-specific Increase in Functional Connectivity.” Neuroimage, 162, 289-296. 2017 Nov 15.

  • Navarro de Lara L & Tik M, Woletz M, Frass-Kriegl R, Moser E, Laistler E, Windischberger C. “High-sensitivity TMS/fMRI of the Human Motor Cortex Using a Dedicated Multichannel MR Coil.” NeuroImage, 2017 Apr 15

Martin Tik

  • ist Associate Editor at Neuroimage: Reports