Metabolism, heart, liver, multi nuclear, sequence development, navigation, motion, image recognition, interleaving
We focus on researching MR imaging and spectroscopy of the heart and skeletal muscles. Cells metabolise carbohydrates and fats to generate Adenosine triphosphate (ATP), the immediate source of energy in tissue. ATP and other important phosphates give rise to MR detectable signals which we study. From these, we derive the metabolic state and cellular pH values.
The relatively slow process of data acquisition in MR requires to take motion into account, especially in organs like the heart. We develop techniques that use MR images to automatically detect and track motion. This requires very rapid acquisition and reconstruction of images.
The biomechanical properties of the myocardium strongly influence the pumping efficiency of the heart. In a current project we develop fully non-invasive measurement of mechanical work of the heart muscle.
If you would like to join our team, please contact us.
Research Area
Team members
Principal Investigator
Albrecht Ingo Schmid
P +43 (0)1 40400-64610
Members
Carla Fink
Lorenz Kiss
Tito Körner
Stefan Wampl
- Georg Fiedler
- Nicole Fichtner
- Roberta Frass-Kriegl
- Martina Ladrova (AÖCZ Semester Scholarship)
- David Melinc
- Saba Shirvani
- Kirl Schewzow
- Alireza Vasfi
- Marcos Wolf
- Development of motion tracking algorithms in magnetic resonance applications (2022)
- Cardiac Efficiency by MR Spectroscopy and Elastography (2021)
FWF (Austrian Science Fund), P 35607 - Quantification of pH in the human myocardium by 7T 31P MRS (2017)
FWF (Austrian Science Fund), Schrödinger Fellowship - Advanced measurement of human cardiac metabolism by interleaved 31P and 1H 7T MR (2016)
FWF (Austrian Science Fund), P 28867
Selected peer-reviewed publications
- S. Wampl, T. Körner, L. Valkovič, S. Trattnig, M. Wolzt, M. Meyerspeer, and A.I. Schmid. Investigating the effect of trigger delay on cardiac 31P MRS signals. Scientific Reports, 11(1), 2021. 10.1038/s41598-021-87063-8.
- A. Apps, L. Valkovič, M. Peterzan, J.Y.C. Lau, M. Hundertmark, W. Clarke, E.M. Tunnicliffe, J. Ellis, D.J. Tyler, S. Neubauer, O.J. Rider, C.T. Rodgers, and A.I. Schmid. Quantifying the effect of dobutamine stress on myocardial Pi and pH in healthy vol-unteers: A 31 P MRS study at 7T.. Magnetic Resonance in Medicine, 85(3):1147–1159, 2021. 10.1002/mrm.28494.
- Meyerspeer M, Magill AW, Kuehne A, Gruetter R, Moser E, Schmid AI. Simultaneous and interleaved acquisition of NMR signals from different nuclei with a clinical MRI scanner.
Magn Reson Med. 2016 Nov;76(5):1636-1641. Epub 2015 Nov 26. - Schmid AI, Meyerspeer M, Robinson SD, Goluch S, Wolzt M, Fiedler GB, Bogner W, Laistler E, Krššák M, Moser E, Trattnig S, Valkovič L. Dynamic PCr and pH imaging of human calf muscles during exercise and recovery us-ing (31) P gradient-Echo MRI at 7 Tesla. Magn Reson Med. 2016 Jun;75(6):2324-31. Epub 2015 Jun 26.
- Schewzow K, Fiedler GB, Meyerspeer M, Goluch S, Laistler E, Wolzt M, Moser E, Schmid AI.
Dynamic ASL and T2-weighted MRI in exercising calf muscle at 7 T: a feasibility study. Magn Reson Med. 2015 Mar;73(3):1190-5. Epub 2014 Apr 17. - Schmid AI, Schewzow K, Fiedler GB, Goluch S, Laistler E, Wolzt M, Moser E, Meyerspeer M. Exercising calf muscle T₂∗ changes correlate with pH, PCr recovery and maximum oxi-dative phosphorylation. NMR Biomed. 2014 May;27(5):553-60. Epub 2014 Mar 9.
- Schewzow, Kiril, Dissertation MUW 2015
- Frass-Kriegl, Master, TU München 2011
- Schmid, Albrecht Ingo, Dissertation TU Wien 2007