Metabolism, heart, liver, multi nuclear, sequence development, navigation, motion, image recognition, interleaving
We focus on researching MR imaging and spectroscopy of the heart and skeletal muscles. Cells metabolise carbohydrates and fats to generate Adenosine triphosphate (ATP), the immediate source of energy in tissue. ATP and other important phosphates give rise to MR detectable signals which we study. From these, we derive the metabolic state and cellular pH values.
The relatively slow process of data acquisition in MR requires to take motion into account, especially in organs like the heart. We develop techniques that use MR images to automatically detect and track motion. This requires very rapid acquisition and reconstruction of images.
The biomechanical properties of the myocardium strongly influence the pumping efficiency of the heart. In a current project we develop fully non-invasive measurement of mechanical work of the heart muscle.
If you would like to join our team, please contact us.
Research Area
Principal Investigator
Albrecht Ingo Schmid
P +43 (0)1 40400-64610
Members
Lorenz Kiss
Tito Körner
Victor de Villedon
Stefan Wampl
- Georg Fiedler
- Carla Fink
- Nicole Fichtner
- Roberta Frass-Kriegl
- Martina Ladrova (AÖCZ Semester Scholarship)
- David Melinc
- Saba Shirvani
- Kirl Schewzow
- Alireza Vasfi
- Marcos Wolf
- Development of motion tracking algorithms in magnetic resonance applications (2022)
- Cardiac Efficiency by MR Spectroscopy and Elastography (2021)
FWF (Austrian Science Fund), P 35607 - Quantification of pH in the human myocardium by 7T 31P MRS (2017)
FWF (Austrian Science Fund), Schrödinger Fellowship - Advanced measurement of human cardiac metabolism by interleaved 31P and 1H 7T MR (2016)
FWF (Austrian Science Fund), P 28867
Selected peer-reviewed publications
-
Stefan Wampl, Tito Körner, Martin Meyerspeer, Maxim Zaitsev, Marcos Wolf, Siegfried Trattnig, Michael Wolzt, Wolfgang Bogner, and Albrecht Ingo Schmid. "A modular motion compensation pipeline for prospective respiratory motion correction of multi-nuclear MR spectroscopy." Scientific Reports, 14(1), 2024. 10.1038/s41598-024-61403-w.
-
Tito Körner, Stefan Wampl, Lorenz Kiss, Gunpreet Oberoi, Ewald Unger, Wolfgang Birkfellner, and Albrecht I. Schmid. "A modular torso phantom featuring a pneumatic stepper and flow for MR sequence development." Frontiers in Physics, 12, 2024. 10.3389/fphy.2024.1369574.
- S. Wampl, T. Körner, L. Valkovič, S. Trattnig, M. Wolzt, M. Meyerspeer, and A.I. Schmid. Investigating the effect of trigger delay on cardiac 31P MRS signals. Scientific Reports, 11(1), 2021. 10.1038/s41598-021-87063-8.
- A. Apps, L. Valkovič, M. Peterzan, J.Y.C. Lau, M. Hundertmark, W. Clarke, E.M. Tunnicliffe, J. Ellis, D.J. Tyler, S. Neubauer, O.J. Rider, C.T. Rodgers, and A.I. Schmid. Quantifying the effect of dobutamine stress on myocardial Pi and pH in healthy vol-unteers: A 31 P MRS study at 7T.. Magnetic Resonance in Medicine, 85(3):1147–1159, 2021. 10.1002/mrm.28494.
- Meyerspeer M, Magill AW, Kuehne A, Gruetter R, Moser E, Schmid AI. Simultaneous and interleaved acquisition of NMR signals from different nuclei with a clinical MRI scanner.
Magn Reson Med. 2016 Nov;76(5):1636-1641. Epub 2015 Nov 26. - Schmid AI, Meyerspeer M, Robinson SD, Goluch S, Wolzt M, Fiedler GB, Bogner W, Laistler E, Krššák M, Moser E, Trattnig S, Valkovič L. Dynamic PCr and pH imaging of human calf muscles during exercise and recovery us-ing (31) P gradient-Echo MRI at 7 Tesla. Magn Reson Med. 2016 Jun;75(6):2324-31. Epub 2015 Jun 26.
- Fink, Carla, FH Oberösterreich 2023
- Schewzow, Kiril, Dissertation MedUni Wien 2015
- Frass-Kriegl, Master, TU München 2011
- Schmid, Albrecht Ingo, Dissertation TU Wien 2007